Horizontal Gene Transfer as a Global Mediator of Antimicrobial Resistance

نویسنده

  • Jennifer Tsang
چکیده

Antimicrobial resistance in pathogenic bacteria has become a serious public health concern as infections with multi-drug resistant bacteria are becoming increasingly difficult to treat. In a recent publication by Hatosy and Martiny, the diversity of antimicrobial resistance genes in marine systems was explored using functional metagenomics. Work from these authors, as well as other studies of antimicrobial resistance in non-clinical environments, emphasize the need for a One Health approach to address problems associated with antimicrobial use and resistance.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Integron-mediated Multidrug Resistance in a Global Collection of Nontyphoidal Salmonella enterica Isolates

Salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons. Clonal expansion and horizontal gene transfer may contribute to the spread of antimicrobial drug-resistance integrons in these organisms. We investigated this resistance and integron carriage among 90 isolates with the ACSSuT phenotype (resistance to ampicil...

متن کامل

The Rising Tide of Antimicrobial Resistance in Aquaculture: Sources, Sinks and Solutions

As the human population increases there is an increasing reliance on aquaculture to supply a safe, reliable, and economic supply of food. Although food production is essential for a healthy population, an increasing threat to global human health is antimicrobial resistance. Extensive antibiotic resistant strains are now being detected; the spread of these strains could greatly reduce medical tr...

متن کامل

Drug resistance determinants in Herring Gulls (Larus argentatus) and human wastewater in Cape Cod

Antibiotic resistant bacteria pose a serious risk in human and veterinary medicine. In 2001, the World Health Organization identified drug resistance as a major threat to global health. Antimicrobial agents are powerful tools used by clinicians to treat bacterial infections, however, these drugs are losing their potency as microbial communities evolve methods to evade or destroy the antibiotics...

متن کامل

Human health consequences of use of antimicrobial agents in aquaculture.

Intensive use of antimicrobial agents in aquaculture provides a selective pressure creating reservoirs of drug-resistant bacteria and transferable resistance genes in fish pathogens and other bacteria in the aquatic environment. From these reservoirs, resistance genes may disseminate by horizontal gene transfer and reach human pathogens, or drug-resistant pathogens from the aquatic environment ...

متن کامل

Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out.

Antimicrobial resistance (AMR) threats are typically represented by bacteria capable of extensive horizontal gene transfer (HGT). One clear exception is Mycobacterium tuberculosis (Mtb). It is an obligate human pathogen with limited genetic diversity and a low mutation rate which lacks any evidence for HGT. Such features should, in principle, reduce its ability to rapidly evolve AMR. We identif...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016